This difference may explain why penis size varies among siblings with the same biological parents. Genetic mutations may also affect penis size and appearance as well as other physical characteristics. While quite rare, genetic conditions sometimes influence penis size include Kallmann syndrome and Klinefelter syndrome. The following factors also affect penis size: Hormones Just as estrogen and progesterone affect female sexual characteristics, such as breasts, hips, and fat storage, male sex hormones, or androgens, contribute to testicular and penile growth. During puberty, the pituitary gland produces more luteinizing hormone LH and follicle-stimulating hormone FSH. LH promotes testosterone production in the Leydig cells of the testicles, and FSH promotes sperm production.
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